Web30 sep. 2024 · The NEET protein family contains a group of highly conserved iron–sulfur proteins that harbor 3Cys-1His [2Fe–2S]-binding CDGSH domain, and … Web1 aug. 2024 · In this study, we demonstrate that Nrf2 depletion prolonged the sleeping time with pentobarbital sedation. Nrf2 depletion maintains high blood levels of pentobarbital, …
Transcriptional regulation of the human ferritin gene by …
Web1 jan. 2024 · LIP may be used for immediate biological processes including DNA synthesis, repair, and cell division, whereas unutilized LIP can be stored in ferritin (FT) [39]. The iron efflux protein FPN can export iron that isn't stored in the FT back into circulation (Fig. 1). Download : Download high-res image (764KB) Download : Download full-size image Web23 nov. 2024 · Here, Nrf2 regulates iron metabolism pathway in response to oxidative and electrophilic stress by activating transcription of genes coding for ferritin … mccormick nursery huntsville al
Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2…
Web21 feb. 2024 · Our data illustrated that ferritinophagy-mediated ferroptosis promoted the EMT inhibition. In addition, activated Nrf2 involved the regulation on both ferroptosis and EMT in response to the alteration in the cellular redox environment. ... NCOA4-mediated ferritin degradation in lysosomes triggered to ferroptosis induction , ... Web1 sep. 2024 · Nrf2 is a crucial negative regulator of ferroptosis and acts through modulating various downstream genes, including SLC7A11, FTH1, and GPX4. ... Ferritin protects cells from oxidative stress-induced cell injury caused by redox active-free iron overload. WebFerritin, an iron storage protein complex including ferritin light chain (FTL) and ferritin heavy chain 1 (FTH1), takes a perilous part in storing intracellular iron. The excessive intracellular Fe 2+ is oxidized to Fe 3+ and released from the cell by the membrane protein ferroportin, also known as SLC11A3 [ 35, 36 ]. lews registration