Mechanistic understanding of human slfn11

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August undefined, 2024

WebSep 13, 2024 · We provide evidence that SLFN11 contributes to regulation of stem cell markers in GBM, promoting the malignant phenotype. In addition, SLFN11 targeting triggers p21 expression and antitumor responses. Our studies define a highly novel function for SLFN11 and identify it as a potential therapeutic target for GBM. Introduction http://labs.biology.ucsd.edu/david/Reprint%20PDFs/2016a.pdf

Mechanistic understanding of human SLFN11 - ProQuest

Weblaboratory to enhance our understanding of zoonosis and disease emergence. When a cross-species viral transmission event occurs, the virus must adapt in order to subvert the restriction factors as they exist in the new host, or perish. In this study, we show that the SLFN11 gene is evolving under positive selection in simian WebNational Center for Biotechnology Information home office busy sign

The role of Schlafen 11 (SLFN11) as a predictive biomarker for

WebRecently, the Schlafen (SLFN) proteins have been identified as a novel interferon-stimulated family with antiviral properties. In this study, we reported that SLFN11 inhibited prototype foamy virus (PFV) replication. Over-expression of human SLFN11 reduced viral production, while knockdown of SLFN11 … WebMechanistic understanding of human SLFN11 Felix J. Metzner, Simon J. Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens; Affiliations Felix J. Metzner … WebSLFN11 has been identified as a predictive biomarker in cancer, as its expression correlates with a beneficial response to DNA damage inducing anticancer drugs. However, the … home office busy light

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell

SLFN11 schlafen family member 11 [ Homo sapiens (human) ]

WebApr 12, 2024 · We explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in the pathogenesis of atherosclerosis (AS). Thrombin-induced differentially expressed genes (DEGs) in HASMCs were identified by analyzing expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, PPI … WebSLFN11 has been identified as a predictive biomarker in cancer, as its expression correlates with a beneficial response to DNA damage inducing anticancer drugs. However, the … home office business deductionWebApr 4, 2024 · SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents. SLFN11 captures … home office built in shelves

"WebFeb 28, 2024 · Methods. Transcriptome analysis was performed in human HCC tissues with or without response to ICIs. A humanized orthotopic HCC mouse model and a co-culture system were constructed, and cytometry by time-of-flight technology was used to explore the function and mechanism of SLFN11 in the immune context of HCC. " - Mechanistic understanding of human slfn11

Mechanistic understanding of human slfn11

Non-human Primate Schlafen11 Inhibits Production of Both …

WebDec 9, 2015 · Understanding the molecular mechanisms behind SLFN11 involvement in DNA damage response will help clarify its clinical importance and may pave the way for human cancer therapies. In this study, we have provided several lines of evidence to show that SLFN11 is a novel endogenous inhibitor of DNA damage response in cancer cells … WebFeb 12, 2024 · Surprisingly, we identified SLFN11, an IFN-inducible gene previously shown to influence tumor cell sensitivity to DNA damaging agents (DDA), as a modulator of HAP1 sensitivity to T cell attack [ 14, 15 ]. Notably, interference with SLFN11 expression reduced sensitivity of HAP1 to both IFN-γ and DNA damaging agents.

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WebFeb 3, 2024 · SLFN11-expressing cancer cells are consistently hypersensitive to a broad range of chemotherapeutic drugs targeting DNA replication, including topoisomerase inhibitors, alkylating agents, DNA synthesis, and poly (ADP-ribose) polymerase (PARP) inhibitors compared to SLFN11-deficient cancer cells, which are chemoresistant ( 1, 2, 4, 8 …

WebMar 21, 2024 · SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents. SLFN11 captures … WebSep 17, 2024 · The mode of ssDNA binding by dimeric SLFN11 suggests a mechanism how the protein might block stalled replication forks. Taken together, our manuscript describes a new avenue to a mechanistic...

WebDec 18, 2024 · For the aforementioned agents, and in multiple cancer cell line panels, the presence of SLFN11 has been shown to correlate with sensitivity, whereas the low or absent expression has been... WebSLFN11 has been identified as a predictive biomarker in cancer, as its expression correlates with a beneficial response to DNA damage inducing anticancer drugs. However, the …

WebJan 15, 2024 · Conclusions: SLFN11 is a relevant predictive biomarker of sensitivity to PARP inhibitor monotherapy in SCLC and we identify combinatorial therapy with TMZ as a particularly promising therapeutic strategy that warrants further clinical investigation. Clin Cancer Res; 23 (2); 523–35. ©2016 AACR. Translational Relevance

WebAug 29, 2024 · SLFN11 is expressed in monocytes and monocyte-derived dendritic cells [ 51] and is upregulated in monocyte-derived dendritic cells upon exposure to IFN-α, LPS, or rhinovirus [ 51 ]. Similar to SLFN5, SLFN11 has been identified as part of the NOTCH1 nuclear interactome [ 53 ]. home office bureau deskWebUnderstanding the predictive biomarker SLFN11 in small cell lung cancer (SCLC) SCLC is a deadly disease that is initially sensitive to various DNA damaging therapies. Current therapy relies on two broadly used chemotherapeutic agents, cisplatin and etoposide. hinge door shower room factoryWebMar 31, 2024 · Human SLFN11 dimer bound to ssDNA PDB DOI: 10.2210/pdb7ZES/pdb EM Map EMD-14692: EMDB EMDataResource Classification: HYDROLASE Organism (s): … hinge door closer adjustmentWebMar 31, 2024 · Mechanistic understanding of human SLFN11. Metzner, F.J. , Wenzl, S.J. , Kugler, M. , Krebs, S. , Hopfner, K.P. , Lammens, K. (2024) Nat Commun 13: 5464-5464 … home office business expensesWebSep 17, 2024 · 17.09.2024 Schlafen 11 (SLFN11) is an interferon-inducible antiviral restriction factor with tRNA endoribonuclease and DNA binding functions. It is recruited to stalled replication forks in response to replication stress and inhibits replication of certain viruses such as the human immunodeficiency virus 1 (HIV-1) by modulating the tRNA pool. home office business tax deductionWebJan 19, 2024 · SLFN11 is a member of the human Schlafen family (SLFN5, 11, 12, 13, and 14). ... the mechanism underlying the function of SLFN11 can be further elucidated. ... 30. Metzner FJ, Wenzl SJ, Kugler M, Krebs S, Hopfner KP, Lammens K. Mechanistic understanding of human SLFN11. Nat Commun (2024) 13:1–10. doi: ... home office butcher block deskWebApr 2, 2024 · This study explored the epigenetic regulation and mechanism of SLFN11 in human gastric cancer. Methods: Eight human gastric cancer cell lines and 201 cases of primary gastric cancer were analyzed. home office cabinet desk