Clec9a ligand
WebMontgomery County, Kansas. Date Established: February 26, 1867. Date Organized: Location: County Seat: Independence. Origin of Name: In honor of Gen. Richard … WebApr 7, 2024 · In the UMAP projections, DCs were clearly separated into CD1C+CLEC10A+ and FLT3+CLEC9A+ DC. Open in a separate window. ... Ligand‐receptor pairs showing interaction between all immune cells and myeloid cells ordered by ligand activity. (D) Uniform manifold approximation and projection (UMAP) plots showing the developmental …
Clec9a ligand
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WebMar 17, 2016 · The crystal structure of CLEC9A was reported in the apo form (PDB ID: 3VPP) (Zhang et al. 2012). The putative ligand recognition site of CLEC9A is similar to those of other CLRs. Two mutations located at this face, W131A and W227A, disrupt the ability to bind F-actin, supporting the idea that this face is a ligand recognition site. WebOct 17, 2012 · CLEC9A, a novel C-type selectin receptor on a subset of DCs, plays an important role in cross-presentation of dead cell-associated antigens. Interestingly, we detected high expression of CLEC9A ligand on autophagosomes.
WebCD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the … WebCLEC9A (C-type lectin domain family 9, a.k.a. DNGR-1 or CD370) is a recently discovered endocytic receptor that is implicated in the clearance of damaged and dead [82, 83] cells. This receptor, currently targeted via antibody, is restricted to a very small population of blood BDCA3 + DCs [ 84 ] (in humans) and its equivalent in mice models is ...
WebMay 1, 2015 · CLEC9A is a damage-associated molecular pattern (DAMP) receptor that senses necrotic cells [27]. Ligation of CLEC9A does not activate DC, but regulates cross-presentation of necrotic cell-associated Ag via recruitment and activation of the tyrosine kinase Syk [27], [28]. However, until recently the ligand for CLEC9A was not known. Web本发明涉及免疫系统的调节，特别是对CLEC9a分子具有亲和力的分子用于引发和抑制针对靶抗原之免疫应答的用途。背景技术免疫系统能够检测传染原的存在，并引发针对它们的应答，而不破坏自身组织。由于病原体巨大的分子多样性以及其高复制和突变速率，该现象并不寻常。多细胞生物在进化过程 ...
WebMay 1, 2024 · Given almost exclusive binding of OVA-Clec9A-TNE to CD8 + DCs and pDCs, the upregulation of maturation markers by Clec9A – CD8 – DCs suggested that ligation of Clec9A and delivery of OVA may have promoted a systemic cytokine response and secondary DC activation.
WebApr 5, 2012 · Clec9A recognizes a conserved component within nucleated and nonnucleated cells, exposed when cell membranes are damaged. We have identified this Clec9A ligand as a filamentous form of actin in … marriage certificate online kdmcWebDec 2, 2024 · At lower pH, both mouse and human Clec9A adopt a reduction-resistant dimer conformation. This reduction-resistant conformation promotes cross-presentation of dead cell-derived Ag, although it does not affect the ability of Clec9A to bind its ligand F-actin, to signal through Syk kinase or to undergo internalization (Hanč et al., 2016). Thus ... nbc sports reporter mariaWebLigand–receptor interactions in CC with different histologic subtypes and HPV infection statuses. A) Dot plots demonstrate selected ligand–receptor interactions between tip cells and other endothelial cells, respectively, in HPV-positive SCC, HPVA ADC and NHPVA ADC. ... [30, 41] In terms of DCs, we identified that CLEC9A+ DCs exerted ... nbc sports replaysWebMar 8, 2012 · CLEC9A is a recently discovered C-type lectin receptor involved in sensing necrotic cells. In humans, this receptor is selectively expressed by BDCA3(+) myeloid … nbc sports resultsWebMay 1, 2015 · Recently, gene expression profiling identified BDCA3+ CLEC9A + DC as a separate human DC subset. This subset was identified in blood, where they represent the smallest population of human DC, as well as in lymphoid and peripheral tissues. marriage certificate online madhya pradeshWebMar 28, 2024 · The oil-in-water nanoemulsion system incorporates and delivers antigens directly to Clec9A, which is responsible for organizing the processing and cross … marriage certificate online pcmcWebCLEC9A Protein Overview: Sequence, Structure, Function and Protein Interaction CLEC9A Protein Overview CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions … marriage certificate online maharashtra form